An internal standard for the quantification of norfloxacin
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Unlabeled Version(s)
25975Norfloxacin
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Norfloxacin-d5

Item No. 28521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(ethyl-1,1,2,2,2-d5)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
CAS Number
1015856-57-1
Molecular Formula
C16H13D5FN3O3
Formula Weight
324.4
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
CHCl3: Slightly soluble: 0.1-1 mg/mlChloroform: slightlyDMSO: Slightly soluble: 0.1-1 mg/mlDMSO: slightly, heated
SMILES
O=C(O)C1=CN(C([2H])([2H])C([2H])([2H])[2H])C2=CC(N3CCNCC3)=C(F)C=C2C1=O
InChi Code
InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)/i1D3,2D2
InChi Key
OGJPXUAPXNRGGI-ZBJDZAJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Item No. 25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).1 It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).2 Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.3 Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Darrell, R.W., Modak, S.M., and Fox, C.L., Jr. Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit. Trans. Am. Opthalmol. Soc. 82, 75-91 (1984).

    2. Awji, E.G., Damte, D., Lee, S.-J., et al. The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogs. J. Vet. Med. Sci. 74(8), 1091-1094 (2012).

    3. Soriano, F., Rodriguez-Tudela, J.L., Castilla, C., et al. Treatment of encrusted cystitis caused by Corynebacterium group D2 with norfloxacin, ciprofloxacin, and teicoplanin in an experimental model in rats. Antimicrob. Agents Chemother. 35(12), 2587-2590 (1991).