An internal standard for the quantification of elvitegravir
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Unlabeled Version(s)
17798Elvitegravir
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Elvitegravir-d6

Item No. 28523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-3-quinolinecarboxylic acid-d6
Molecular Formula
C23H17ClD6FNO5
Formula Weight
453.9
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
ClC1=CC=CC(C([2H])([2H])C2=CC(C(C(C(O)=O)=CN3[C@@H](C(C)C)CO)=O)=C3C([2H])=C2OC([2H])([2H])[2H])=C1F.ClC4=CC=CC(C([2H])([2H])C5=C([2H])C(C(C(C(O)=O)=CN6[C@@H](C(C)C)CO)=O)=C6C=C5OC([2H])([2H])[2H])=C4F.ClC7=CC=CC(C([2H])([2H])C8=CC(C(C(C(O)=O)=C([2H])N9[C@@H](C(C)C)CO)=O)=C9C=C8OC([2H])([2H])[2H])=C7F
InChi Code
InChI=1S/3C23H23ClFNO5/c3*1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h3*4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t3*19-/m111/s1/i3D3,7D2,10D;3D3,7D2,9D;3D3,7D2,8D
InChi Key
VSMSHPLOKWSOMS-HMHRCWKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $356

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    Product Description

    Elvitegravir-d6 is intended for use as an internal standard for the quantification of elvitegravir (Item No. 17798) by GC- or LC-MS. Elvitegravir is a quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM).1 It has antiviral activity against laboratory strains and clinical isolates of HIV-1 (EC50s = 0.1-1.26 nM) in MAGI cells and HIV-2 (EC50s = 0.3-0.9) in peripheral blood mononuclear cells (PBMCs).1,2 Formulations containing elvitegravir have been used in the treatment of HIV infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, M., Motomura, T., Aramaki, H., et al. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J. Med. Chem. 49(5), 1506-1508 (2006).

    2. Roquebert, B., Damond, F., Collin, G., et al. HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. J. Antimicrob. Chemother. 62(5), 914-920 (2008).