An internal standard for the quantification of corticosterone
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Corticosterone-d8

Item No. 28524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-11,21-dihydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,17,21,21-d8
CAS Number
1271728-07-4
Synonyms
  • 17-deoxy Cortisol-d8
  • 11β,21-DHP-d8
  • 11β,21-dihydroxy Progesterone-d8
Molecular Formula
C21H22D8O4
Formula Weight
354.5
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: slightly solubleMethanol: slightly soluble
SMILES
O=C1C([2H])([2H])C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4([2H])C(C([2H])([2H])O)=O)=C1[2H]
InChi Code
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1/i3D2,7D2,9D,11D2,16D
InChi Key
OMFXVFTZEKFJBZ-VWODBOJYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Corticosterone-d8 is intended for use as an internal standard for the quantification of corticosterone (Item No. 16063) by GC- or LC-MS. Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors.1 It is produced in response to adrenocorticotropic hormone (ACTH) and is the precursor to aldosterone synthesis.2 Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress.3 Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.4,5

    WARNING This product is not for human or veterinary use.