An internal standard for the quantification of ciclesonide
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Unlabeled Version(s)
18227Ciclesonide
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Ciclesonide-d7

Item No. 28527

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β,16α)-16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-[2-(methyl-d3)-1-oxopropoxy-2,3,3,3-d4]-pregna-1,4-diene-3,20-dione
CAS Number
1225382-70-6
Synonyms
  • CIC-d7
Molecular Formula
C32H37D7O7
Formula Weight
547.7
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(COC(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=O)O[C@@](C6CCCCC6)([H])O5)=C1
InChi Code
InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1/i1D3,2D3,18D
InChi Key
LUKZNWIVRBCLON-BLMCDVGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $307

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    Product Description

    Ciclesonide-d7 is intended for use as an internal standard for the quantification of ciclesonide (CIC; Item No. 18227) by GC- or LC-MS. Ciclesonide is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).1 CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.2 It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Derendorf, H., Nave, R., Drollmann, A., et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. Eur. Respir. J. 28(5), 1042-1050 (2006).

    2. Belvisi, M.G., Bundschuh, D.S., Stoeck, M., et al. Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma. J. Pharmacol. Exp. Ther. 314(2), 568-574 (2005).