A fungal metabolite
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Hypocrellin B

Item No. 28544

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dione
CAS Number
123940-54-5
Molecular Formula
C30H24O9
Formula Weight
528.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: soluble
λmax
336, 461, 549 nm
SMILES
CC(C1)=C(C(C)=O)C(C2=C3C(C(OC)=CC(O)=C34)=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C4=O
InChi Code
InChI=1S/C30H24O9/c1-10-7-12-18-23-19(27(34)29(12)38-5)13(32)8-15(36-3)21(23)22-16(37-4)9-14(33)20-25(22)24(18)26(17(10)11(2)31)30(39-6)28(20)35/h8-9,32-33H,7H2,1-6H3
InChi Key
APTUSGMALOMQQL-UHFFFAOYSA-N
Origin
Fungus/Hypocrella bambusae
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

    $514

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    Product Description

    Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.1,2 It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.1 It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jia, Y., Wang, X., Liu, Q., et al. Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway. Ultrasonics 73, 154-161 (2017).

    2. Leung, A.W.N., Ip, M., Xu, C.S., et al. Sonodynamic bactericidal efficacy of hypocrellin A and B against methicillin-resistant Staphylococcus aureus. Hong Kong Med. J. 23 Suppl 5(4), 36-37 (2017).