A solvatochromic fluorophore and pH probe
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ICAAc

Item No. 28564

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-isocyanoacridin-3-amine
Synonyms
  • 3-amino-6-Isocyanoacridine
Molecular Formula
C14H9N3
Formula Weight
219.2
Purity
≥98%
Emission
abs/em = 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous buffer
Excitation
466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.1 mg/mlEthanol: 1 mg/ml
λmax
245, 288 nm
SMILES
NC1=CC2=C(C=C1)C=C3C(C=C(C=C3)[N+]#[C-])=N2
InChi Code
InChI=1S/C14H9N3/c1-16-12-5-3-10-6-9-2-4-11(15)7-13(9)17-14(10)8-12/h2-8H,15H2
InChi Key
GXXTUSOSNDNJFZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $77

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    10 mg

    $129

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    25 mg

    $263

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    Product Description

    ICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).