A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3
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AUT1

Item No. 28599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5R-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
CAS Number
1311136-84-1
Molecular Formula
C18H19N3O4
Formula Weight
341.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 5 mg/ml
λmax
277 nm
SMILES
CC1=CC=C(OC2=CC=C(N3C(N[C@H](CC)C3=O)=O)C=N2)C=C1OC
InChi Code
InChI=1S/C18H19N3O4/c1-4-14-17(22)21(18(23)20-14)12-6-8-16(19-10-12)25-13-7-5-11(2)15(9-13)24-3/h5-10,14H,4H2,1-3H3,(H,20,23)/t14-/m1/s1
InChi Key
AMAOXEGBJHLCSF-CQSZACIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    Product Description

    AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 µM, respectively, in a patch-clamp assay).1 It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosato-Siri, M.D., Zambello, E., Mutinelli, C., et al. A novel modulator of Kv3 potassium channels regulates the firing of parvalbumin-positive cortical interneurons. J. Pharmacol. Exp. Ther. 354(3), 251-260 (2015).