An oxidation product of oleic acid
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9,10-Dihydroxystearic Acid

Item No. 28612

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,10-dihydroxy-octadecanoic acid
CAS Number
120-87-6
Synonyms
  • NSC 60305
Molecular Formula
C18H36O4
Formula Weight
316.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:5): 0.16mg/mLEthanol: 5mg/mL
SMILES
OC(CCCCCCCC(O)C(O)CCCCCCCC)=O
InChi Code
InChI=1S/C18H36O4/c1-2-3-4-5-7-10-13-16(19)17(20)14-11-8-6-9-12-15-18(21)22/h16-17,19-20H,2-15H2,1H3,(H,21,22)
InChi Key
VACHUYIREGFMSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $329

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    25 mg

    $702

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    Product Description

    9,10-Dihydroxystearic acid is an oxidation product of oleic acid (Item Nos. 90260 | 24659) that can be formed from oleic acid in HepG2 cells.1 It activates peroxisome proliferator-activated receptor α (PPARα) in CV-1 cells when used at concentrations ranging from 50 to 100 µM.2 9,10-Dihydroxystearic acid (4% in the diet) decreases blood glucose levels, increases insulin sensitivity, and decreases body weight in high-fat diet-fed KKAy diabetic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jing, H.-J., Zhang, Y.-H., Wang, J., et al. Conversion of oleic acid to 9,10-dihydroxystearic acid in human hepatic cancer HepG2 cells. Junyi Jinxiu Xueyuan Xuebao 31(6), 597-599 (2010).

    2. Yu, X., Zhang, Y., Liu, Y., et al. Effects of 9,10-dihydroxysteatic acid on glucose metabolism in KKAy mice. Wei Sheng Yan Jiu 39(4), 423-425 (2010).