An internal standard for the quantification of meropenem
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Unlabeled Version(s)
16068Meropenem (hydrate)
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Meropenem-d6

Item No. 28616

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R,5S,6S)-3-[[(3S,5S)-5-[[di(methyl-d3)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS Number
1133424-00-6
Molecular Formula
C17H19D6N3O5S
Formula Weight
389.5
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble
SMILES
O=C(O)C1=C(S[C@@H]2CN[C@H](C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C2)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O
InChi Code
InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1/i3D3,4D3
InChi Key
DMJNNHOOLUXYBV-ZSJYILIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $369

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    Product Description

    Meropenem-d6 is intended for use as an internal standard for the quantification of meropenem (Item No. 16068) by GC- or LC-MS. Meropenem is a carbapenem antibiotic.1 It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively.2 Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edwards, J.R., Turner, P.J., Wannop, C., et al. In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I. Antimicrob. Agents Chemother. 33(2), 215-222 (1989).

    2. Edwards, J.R., Williams, S., and Nairn, K. Therapeutic activity of meropenem in experimental infections. J. Antimicrob. Chemother. 24(Suppl. A), 279-285 (1989).