For immunochemical detection of ganglioside GD1b
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Ganglioside GD1b Polyclonal Antibody

Item No. 28642

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
Purified ganglioside GD1b and complete Freund’s adjuvant
Source
Rabbit
Formulation (Request formulation change)
50 µl of polyclonal antibody to ganglioside GD1b
Solubility(Learn about Variance in Solubility)
Water: soluble
Host
Rabbit
Isotype
IgG/IgM
Applications
ELISA, TLC Immunoblotting
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µl

    $523

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    Product Description

    Ganglioside GD1b (Item No. 19569) is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events.1 The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects.2 Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.3 Ganglioside GD1b Polyclonal Antibody can be used for ELISA and TLC immunoblotting applications. [Matreya, LLC. Catalog No. 1964]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolter, T. Ganglioside biochemistry. ISRN Biochem. 506160 (2012).

    2. Riboni, L., Sonnino, S., Acquotti, D., et al. Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain. The Journal of Biological Chemisty 261(18), 8514-8519 (1986).

    3. Comas, T.C., Tai, T., Kimmel, D., et al. Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors. Neuro Oncol. 1(4), 261-267 (1999).