Ciclopirox-d₁₁ (sodium salt)

Ciclopirox-d₁₁ (sodium salt) is intended for use as an internal standard for the quantification of ciclopirox (Item No. 16021) by GC- or LC-MS. Ciclopirox is an iron chelator, antifungal, and anticancer agent.^1,2,3,4 It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC₅₀ = 1.58 μM), an effect that is reduced in the presence of iron.¹ It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.⁵ Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.^2,3 It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G₁/G₀ phase and induces apoptosis in Rh30 cells.⁴ Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.

WARNING This product is not for human or veterinary use.