An internal standard for the quantification of amprenavir
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Unlabeled Version(s)
15369Amprenavir
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Amprenavir-d4

Item No. 28703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R)-3-[[(4-aminophenyl-d4)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester
CAS Number
2738376-78-6
Synonyms
  • APV-d4
  • Prozei-d4
Molecular Formula
C25H31D4N3O6S
Formula Weight
509.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleMethanol: soluble
SMILES
NC1=C([2H])C([2H])=C(S(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CCOC3)=O)CC(C)C)(=O)=O)C([2H])=C1[2H]
InChi Code
InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1/i8D,9D,10D,11D
InChi Key
YMARZQAQMVYCKC-MHVPRHJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Amprenavir-d4 is intended for use as an internal standard for the quantification of amprenavir (Item No. 15369) by GC- or LC-MS. Amprenavir is an inhibitor of HIV protease (Ki = 0.04 nM).1 It inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 150 nM). Formulations containing amprenavir have been used in combination with other antiretroviral agents in the treatment of HIV-1 infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sherrill, R.G., Furfine, E.S., Hazen, R.J., et al. Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors. Bioorg. Med. Chem. Lett. 15(15), 3560-3564 (2005).