A protease inhibitor
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JCP251

Item No. 28712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-amino-4-chloro-3-methoxy-1H-2-benzopyran-1-one
CAS Number
62252-26-0
Synonyms
  • JLK 6
Molecular Formula
C10H8ClNO3
Formula Weight
225.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml
λmax
238, 290 nm
SMILES
NC1=CC=C2C(C(OC(OC)=C2Cl)=O)=C1
InChi Code
InChI=1S/C10H8ClNO3/c1-14-10-8(11)6-3-2-5(12)4-7(6)9(13)15-10/h2-4H,12H2,1H3
InChi Key
AMDGKLWVCUXONP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $87

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    10 mg

    $165

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    50 mg

    $653

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    100 mg

    $1,043

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    JCP251 is a protease inhibitor.1 It inhibits neutrophil elastase when used at a concentration of 5 µM and reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, when used at a concentration of 100 µM in cell-free assays.1,2 JCP251 decreases amyloid-β (1-40) (Aβ40; Item No. 21617) and Aβ42 (Item No. 20574) levels in HEK293 cells expressing wild-type and Swedish mutant amyloid precursor peptide (APP; IC50s = ~30 µM for both).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harper, J.W., and Powers, P.C. 3-Alkoxy-7-amino-4-chloroisocoumarins: A new class of suicide substrates for serine proteases. J. Am. Chem. Soc. 106(24), 7618-7619 (1984).

    2. Bihel, F., Quéléver, G., Lelouard, H., et al. Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease. Bioorg. Med. Chem. 11(14), 3141-3152 (2003).

    3. Petit, P., Pasini, A., da Costa, C.A., et al. JLK isocoumarin inhibitors: Selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. J. Neurosci. Res. 74(3), 370-377 (2003).