An inhibitor of GGTase I
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GGTI 2418

Item No. 28714

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-L-leucine
CAS Number
501010-06-6
Molecular Formula
C23H31N5O4
Formula Weight
441.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1[C@H](CC2=CC=CC=C2)N(C(N[C@H](C(O)=O)CC(C)C)=O)CCN1CC3=C(C)N=CN3
InChi Code
InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1
InChi Key
COLCNDRDBCLVOC-ICSRJNTNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $79

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    5 mg

    $289

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    10 mg

    $534

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    Cayman Chemical
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    Product Description

    GGTI 2418 is an inhibitor of geranylgeranyl transferase type I (GGTase I; IC50 = 9.5 nM).1 It is selective for GGTase I over farnysltransferase (FTase; IC50 = 53,000 nM). GGTI 2418 (100 mg/kg) reduces tumor growth in an MDA-MB-231 breast cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kazi, A., Carie, A., Blaskovich, M.A., et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: Implications for breast cancer therapy. Mol. Cell Biol. 29(8), 2254-2263 (2009).