An inhibitor of hematopoietic-type PGDS
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Prostaglandin D Synthase (hematopoietic-type) Inhibitor F092

Item No. 28721

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(2-oxo-1-pyrrolidinyl)phenyl]-2-(2-pyridinyl)-5-pyrimidinecarboxamide
CAS Number
2250261-59-5
Molecular Formula
C20H17N5O2
Formula Weight
359.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: partially solublePBS (pH 7.2): partially soluble
λmax
256, 285 nm
SMILES
O=C(NC1=CC=C(N2CCCC2=O)C=C1)C(C=N3)=CN=C3C4=CC=CC=N4
InChi Code
InChI=1S/C20H17N5O2/c26-18-5-3-11-25(18)16-8-6-15(7-9-16)24-20(27)14-12-22-19(23-13-14)17-4-1-2-10-21-17/h1-2,4,6-10,12-13H,3,5,11H2,(H,24,27)
InChi Key
MYYXEGDPWAHVAZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

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    10 mg

    $461

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    Product Description

    Prostaglandin D synthase (hematopoietic-type) inhibitor F092 is an inhibitor of hematopoietic-type prostaglandin D synthase (H-PGDS; KD = 0.14 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takaya, D., Inaka, K., Omura, A., et al. Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies. Bioorg. Med. Chem. 26(16), 4726-4734 (2018).