A radical SAM enzyme substrate
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Product Type

Biochemicals

Research Area

Epigenetics, Transcription, & Translation

SAHO2

Item No. 28726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-[[(3S)-3-amino-3-carboxypropyl]sulfonyl]-5′-deoxy-adenosine
CAS Number
53199-56-7
Molecular Formula
C14H20N6O7S
Formula Weight
416.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
235 nm
SMILES
O[C@H]1[C@@H](O)[C@@](N2C=NC3=C(N)N=CN=C32)([H])O[C@@H]1CS(CC[C@H](N)C(O)=O)(=O)=O
InChi Code
InChI=1S/C14H20N6O7S/c15-6(14(23)24)1-2-28(25,26)3-7-9(21)10(22)13(27-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChi Key
NUBHDZKYWTVIHP-WFMPWKQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $289

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    Product Description

    SAHO2 is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and is a substrate for radical SAM enzymes.1 It is reductively cleaved to 5'-deoxyadenosine (Item No. 29619) and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandalapu, D., Ji, X., and Zhang, Q. Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymes. Biochemistry 58(1), 36-39 (2019).