An ERβ agonist
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ERB 041

Item No. 28737

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
CAS Number
524684-52-4
Molecular Formula
C15H10FNO3
Formula Weight
271.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/ml
λmax
216, 247, 309, 338 nm
SMILES
C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1
InChi Code
InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2
InChi Key
MQIMZDXIAHJKQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $96

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    10 mg

    $171

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    Product Description

    ERB 041 is an estrogen receptor β (ERβ) agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively).1 It is selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for human, rat, and mouse ERα, respectively). ERB 041 induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM). In vivo, ERB 041 (0.1 and 0.3 mg/kg) inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease. It reduces joint swelling in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. ERB 041 (10 mg/kg) also reduces lesion formation in a mouse model of endometriosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harris, H.A., Albert, L.M., Leathurby, Y., et al. Evaluation of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144(10), 4241-4249 (2003).

    2. Harris, H.A., Bruner-Tran, K.L., Zhang, X., et al. A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosis. Hum. Reprod. 20(4), 936-941 (2005).