An agonist of PAR2
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AC-264613

Item No. 28777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4S)-rel-2-oxo-4-phenyl-3-pyrrolidinecarboxylic acid, 2-[1-(3-bromophenyl)ethylidene]hydrazide
CAS Number
1051487-82-1
Molecular Formula
C19H18BrN3O2
Formula Weight
400.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 40 mg/ml
SMILES
BrC1=CC(/C(C)=N/NC([C@@H]2C(NC[C@@]2([H])C3=CC=CC=C3)=O)=O)=CC=C1
InChi Code
InChI=1S/C19H18BrN3O2/c1-12(14-8-5-9-15(20)10-14)22-23-19(25)17-16(11-21-18(17)24)13-6-3-2-4-7-13/h2-10,16-17H,11H2,1H3,(H,21,24)(H,23,25)/b22-12+/t16-,17-/m0/s1
InChi Key
RQKXQCSEZPQBNZ-QSBCOWLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $534

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    Product Description

    AC-264613 is an agonist of proteinase-activated receptor 2 (PAR2).1 It induces calcium mobilization, phosphatidylinositol hydrolysis, and cell proliferation in NIH3T3 cells expressing PAR2 (EC50s = 100, 125.8, and 31.6 nM, respectively). AC-264613 (3 µg/paw) induces paw edema and thermal hyperalgesia in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gardell, L.R., Ma, J.N., Seitzberg, J.G., et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J. Pharmacol. Exp. Ther. 327(3), 799-808 (2008).