An inducer of ferroptosis
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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Item No. 28788

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-5-13)-chloro[[2,2′-[1,2-phenylenebis[(nitrilo-κN)methylidyne]]bis[phenolato-κO]](2-)]-iron
CAS Number
39916-28-4
Synonyms
  • Iron Salophene Complex
  • [N,N'-o-Phenylenebis(salicylideneaminato)]iron(III) Chloride
Molecular Formula
C20H14ClFeN2O2
Formula Weight
405.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 0.3 mg/mlPBS (pH 7.2): Partially soluble
λmax
244, 302, 375 nm
SMILES
[Cl-][Fe+3]12([N]3=CC4=CC=CC=C4[O-]2)[N](C5=CC=CC=C35)=CC6=CC=CC=C6[O-]1
InChi Code
InChI=1S/C20H16N2O2.ClH.Fe/c23-19-11-5-1-7-15(19)13-21-17-9-3-4-10-18(17)22-14-16-8-2-6-12-20(16)24;;/h1-14,23-24H;1H;/q;;+3/p-3/b21-13+,22-14+;;
InChi Key
RCXMCWQRRLCOAJ-FDOBHKDXSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 µM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 µM, respectively), as well as NALM-6 cells resistant to daunorubicin (Item No. 14159) and vincristine (Item No. 11764) when used at concentrations ranging from 0.04 to 0.125 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sagasser, J., Ma, B., Baecker, D., et al. A new approach in cancer treatment: Discovery of chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers. J. Med. Chem. 62(17), 8053-8061 (2019).

    2. Lee, S.-Y., Hille, A., Kitanovic, I., et al. [FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells. Leuk. Res. 35(3), 387-393 (2011).