A cathepsin L inhibitor
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Cathepsin Inhibitor 1

Item No. 28790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-[(3-chlorophenyl)methyl]-2-[(cyanomethyl)amino]-2-oxoethyl]-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS Number
225120-65-0
Molecular Formula
C20H24ClN5O2
Formula Weight
401.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
O=C(N[C@@H](CC1=CC(Cl)=CC=C1)C(NCC#N)=O)C2=CC(C(C)(C)C)=NN2C
InChi Code
InChI=1S/C20H24ClN5O2/c1-20(2,3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7,10,12,15H,9,11H2,1-4H3,(H,23,27)(H,24,28)/t15-/m0/s1
InChi Key
MZRVIHRERYCHBL-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $165

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    50 mg

    $379

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    Product Description

    Cathepsin inhibitor 1 is an inhibitor of cathepsin L (IC50 = 12.58 nM).1 It is selective for cathepsin L over cathepsin L2, cathepsin S, cathepsin K, and cathepsin B (IC50s = 199.53, 1,000, 3,162.27, and 6,309.57 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Assad, N., Bethel, P.A., Coulson, M.D., et al. Dipeptidyl nitrile inhibitors of cathepsin L. Bioorg. Med. Chem. Lett. 19(15), 4280-4283 (2009).