An internal standard for the quantification of cytarabine
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Unlabeled Version(s)
16069Cytarabine
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Cytarabine-13C3

Item No. 28805

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone-4,5,6-13C3
Synonyms
  • Ara-C-13C3
  • 1-β-D-Arabinofuranosylcytosine-13C3
Molecular Formula
C6[13C3]H13N3O5
Formula Weight
246.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: warmedWater: slightly soluble
SMILES
O[C@@H]1[C@H](N2C(N=[13C](N)[13CH]=[13CH]2)=O)O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1/i1+1,2+1,5+1
InChi Key
UHDGCWIWMRVCDJ-BOZZUQJYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $290

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    Product Description

    Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.1 It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.2 Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.3 It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.1 Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.4 It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.5 Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Z., Guo, J.-R., Chen, Q.-Q., et al. Exploring the antitumor mechanism of high-dose cytarabine through the metabolic perturbations of ribonucleotide and deoxyribonucleotide in human promyelocytic leukemia HL-60 cells. Molecules 22(3), E499 (2017).

    2. Emadi, A., and Karp, J.E. The clinically relevant pharmacogenomic changes in acute myelogenous leukemia. Pharmacogenomics 13(11), 1257-1269 (2012).

    3. Qin, T., Youssef, E.M., Jelinek, J., et al. Effect of cytarabine and decitabine in combination in human leukemic cell lines. Clin. Cancer Res. 13(14), 4225-4232 (2007).

    4. Kelly, K.R., Espitia, C.M., Taverna, P., et al. Targeting PIM kinase activity significantly augments the efficacy of cytarabine. Br. J. Haematol. 156(1), 129-132 (2012).

    5. Renis, H.E. Antiviral activity of cytarabine in Herpesvirus–infected rats. Antimicrob. Agents Chemother. 4(4), 439-444 (1973).