A sulfonamide antibiotic
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Sulfadimethoxine

Item No. 28827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamide
CAS Number
122-11-2
Synonyms
  • Sulphadimethoxine
Molecular Formula
C12H14N4O4S
Formula Weight
310.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMF:PBS (pH 7.2) (1:7): 0.16mg/mLDMSO: 10mg/mL
λmax
273 nm
SMILES
COC1=NC(OC)=CC(NS(C2=CC=C(N)C=C2)(=O)=O)=N1
InChi Code
InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
InChi Key
ZZORFUFYDOWNEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.1 It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.2 Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.1 It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).3,4 Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Böhni, E., Fust, B., Rieder, J., et al. Comparative toxicological, chemotherapeutic and pharmacokinetic studies with sulphormethoxine and other sulphonamides in animals and man. Chemotherapy 14(4), 195-226 (1969).

    2. Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 39(8), 1756-1763 (1995).

    3. Agnoletti, F., Ferro, T., Guolo, A., et al. A survey of Clostridium spiroforme antimicrobial susceptibility in rabbit breeding. Vet. Microbiol. 136(1-2), 188-191 (2009).

    4. Angelos, J.A., Ball, L.M., and Byrne, B.A. Minimum inhibitory concentrations of selected antimicrobial agents for Moraxella bovoculi associated with infectious bovine keratoconjunctivitis. J. Vet. Diagn. Invest. 23(3), 552-555 (2011).