An HDAC8 inhibitor
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HDAC8-IN-1

Item No. 28832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-hydroxy-3-(5-methoxy[1,1′:4′,1′′-terphenyl]-2-yl)-2-propenamide
CAS Number
1417997-93-3
Synonyms
  • MDK-7933
  • WK2-16
Molecular Formula
C22H19NO3
Formula Weight
345.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
COC1=CC=C(/C=C/C(NO)=O)C(C2=CC=C(C3=CC=CC=C3)C=C2)=C1
InChi Code
InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+
InChi Key
ASHPRZYGCOMVHO-WYMLVPIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $762

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    Product Description

    HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC50 = 27.2 nM).1 It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, W.-J., Wang, Y.-C., Chao, S.-W., et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem 7(10), 1815-1824 (2012).