An adenosine analog
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N6-Methyladenosine

Item No. 28833

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-adenosine
CAS Number
1867-73-8
Synonyms
  • NSC 29409
Molecular Formula
C11H15N5O4
Formula Weight
281.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
266 nm
SMILES
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NC)N=CN=C32
InChi Code
InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1
InChi Key
VQAYFKKCNSOZKM-IOSLPCCCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    N6-Methyladenosine is an adenosine analog.1 It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs.2 It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas.3 N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leslie, S.W., Borowitz, J.L., and Miya, T.S. Adenosine analogs: Structure-activity relationships in vascular and intestinal smooth muscle. J. Pharm. Sci. 62(9), 1449-1452 (1973).

    2. Bhanalaph, T., Mittelman, A., Ambrus, J.L., et al. Effect of adenosine and some of its analogs on renal hemodyamics. J. Med. 4(3), 178-188 (1973).

    3. Strong, L.C., and Matsunaga, H. Comparison of the effect of three nucleosides and a liver emulsion upon the inhibition of cancer in mice. J. Surg. Oncol. 4(3), 248-254 (1972).

    4. Wang, X., Lu, Z., Gomez, A., et al. N6-Methyladenosine-dependent regulation of messenger RNA stability. Nature 505(7481), 117-120 (2014).