A positive allosteric modulator of NR2C subunit-containing NMDARs
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PYD-106

Item No. 28837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-acetyl-2,5-dihydro-4-hydroxy-1-[2-(2-methyl-1H-indol-3-yl)ethyl]-5-oxo-1H-pyrrol-2-yl]-benzoic acid, methyl ester
CAS Number
1560894-05-4
Molecular Formula
C25H24N2O5
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
226, 248 nm
SMILES
CC1=C(CCN2C(C3=CC=C(C(OC)=O)C=C3)C(C(C)=O)=C(O)C2=O)C4=CC=CC=C4N1
InChi Code
InChI=1S/C25H24N2O5/c1-14-18(19-6-4-5-7-20(19)26-14)12-13-27-22(21(15(2)28)23(29)24(27)30)16-8-10-17(11-9-16)25(31)32-3/h4-11,22,26,29H,12-13H2,1-3H3
InChi Key
LIFGURQFZLMSDE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $69

    Add

    5 mg

    $263

    Add

    10 mg

    $493

    Add
    Product Description

    PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).1 It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khatri, A., Burger, P.B., Swanger, S.A., et al. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol. Pharmacol. 86(5), 548-560 (2014).