An inhibitor of PARP10
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OUL35

Item No. 28845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-oxybis-benzamide
CAS Number
6336-34-1
Synonyms
  • NSC 39047
Molecular Formula
C14H12N2O3
Formula Weight
256.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
258 nm
SMILES
NC(C1=CC=C(OC2=CC=C(C(N)=O)C=C2)C=C1)=O
InChi Code
InChI=1S/C14H12N2O3/c15-13(17)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18)
InChi Key
XZRCQWLPMXFGHE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $168

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    25 mg

    $370

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    Cayman Chemical
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    Product Description

    OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).1 It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Item No. 23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Venkannagari, H., Verheugd, P., Koivunen, J., et al. Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem. Bio. 23(10), 1251-1260 (2016).