Pentanoic Acid-d₉

Pentanoic acid-d₉ is intended for use as an internal standard for the quantification of pentanoic acid by GC- or LC-MS. Pentanoic acid is a short-chain saturated fatty acid. It is a gut microbiota metabolite and has also been found in the essential oil of V. alliariifolia and in goat milk.¹,^2,3 Pentanoic acid (0.85 mM) inhibits the proliferation, migration, and invasion of Hep3B, SNU-449, and HepG2 liver cancer cells.⁴ It increases survival and prevents increases in peripheral blood levels of IL-6, TNF-α, and malondialdehyde (MDA) in irradiated mice, as well as prevents decreases in colon length in a mouse model of colitis induced by dextran sodium sulfate (DSS; Item No. 23250), when administered at a concentration of 0.3 mg/ml in the drinking water.⁵ Fecal levels of pentanoic acid are increased in patients with colorectal cancer.¹

WARNING This product is not for human or veterinary use.

1. Weir, T.L., Manter, D.K., Sheflin, A.M., et al. Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One 8(8), 70803 (2013).

2. Bardakci, H., Demirci, B., Yesilada, E., et al. Chemical composition of the essential oil of the subterranean parts of Valeriana alliariifolia. Rec. Nat. Prod. 6(1), 89-92 (2012).

3. Sant'Ana, A.M.S., Bessa, R.J.B., Alves, S.P., et al. Fatty acid, volatile and sensory profiles of milk and cheese from goats raised on native semiarid pasture or in confinement. Int. Dairy J. 91, 147-154 (2018).

4. Han, R., Nusbaum, O., Chen, X., et al. Valeric acid suppresses liver cancer development by acting as a novel HDAC inhibitor. Mol. Ther. Oncolytics 19, 8-18 (2020).

5. Li, Y., Dong, J., Xiao, H., et al. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes 11(4), 789-806 (2020).