An internal standard for the quantification of balsalazide
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Unlabeled Version(s)
18680Balsalazide
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Balsalazide-d4

Item No. 28888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-5-((4-((2-carboxyethyl)carbamoyl)phenyl-2,3,5,6-d4)diazenyl)-2-hydroxybenzoic acid
Molecular Formula
C17H11D4N3O6
Formula Weight
361.3
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
OC1=CC=C(/N=N/C2=C([2H])C([2H])=C(C(NCCC(O)=O)=O)C([2H])=C2[2H])C=C1C(O)=O
InChi Code
InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+/i1D,2D,3D,4D
InChi Key
IPOKCKJONYRRHP-AAMHWJAJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $436

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    Product Description

    Balsalazide-d4 is intended for use as an internal standard for the quantification of balsalazide (Item No. 18680) by GC- or LC-MS. Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).1 It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).2 Formulations containing balsalazide have been used in the treatment of ulcerative colitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tursi, A. Balsalazide in treating colonic diseases. Expert Opin. Drug Metab. Toxicol. 5(12), 1555-1563 (2009).

    2. Lu, Y.-X., and Chen, X.-M. Effects of balsalazide on experimental colitis induced by 2,4-dinitrochlorobenzene in rats. Zhongguo Xinyao Yu Linchuang Zazhi 26(12), 901-904 (2007).