An internal standard for the quantification of tipranavir
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Unlabeled Version(s)
21028Tipranavir
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Tipranavir-d4

Item No. 28907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-((R)-1-((R)-4-hydroxy-2-oxo-6-phenethyl-6-(propyl-1,1,2,2-d4)-5,6-dihydro-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
CAS Number
1217819-15-2
Molecular Formula
C31H29D4F3N2O5S
Formula Weight
606.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethyl Acetate: solubleMethanol: soluble
SMILES
O=S(C1=NC=C(C(F)(F)F)C=C1)(NC2=CC([C@H](C3=C(O)C[C@@](C([2H])([2H])C([2H])([2H])C)(CCC4=CC=CC=C4)OC3=O)CC)=CC=C2)=O
InChi Code
InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1/i3D2,16D2
InChi Key
SUJUHGSWHZTSEU-YBLLDNOUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $436

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    Product Description

    Tipranavir-d4 is intended for use as an internal standard for the quantification of tipranavir (Item No. 21028) by GC- or LC-MS. Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = <1 nM) that prevents cleavage and thus activation of functional HIV-cleaved proteins.1,2 Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used in the treatment of HIV infection progression in patients who have not responded well to initial treatments.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thaisrivongs, S., and Strohbach, J.W. Structure-based discovery of Tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor. Biopoly. 51(1), 51-58 (1999).

    2. Turner, S.R., Strohbach, J.W., Tommasi, R.A., et al. Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J. Med. Chem. 41(18), 3467-3476 (1998).