A peptide agonist of δ-opioid receptors
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Isomer(s)
35198Pentapeptide-18 (acetate)
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DADLE

Item No. 28928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine
CAS Number
63631-40-3
Synonyms
  • [D-Ala2, D-Leu5]-Enkephalin
Molecular Formula
C29H39N5O7
Formula Weight
569.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)C=C1
InChi Code
InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
InChi Key
ZHUJMSMQIPIPTF-IBURTVSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    50 mg

    $835

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    Product Description

    DADLE is a peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay).1 It is selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes μ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively). It induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corbett, A.D., Gillan, M.G.C., Kosterlitz, H.W., et al. Selectivities of opioid peptide analogues as agonists and antagonists at the δ-receptor. Br. J. Pharmacol. 83(1), 271-279 (1984).

    2. Suh, H.H., and Tseng, L.F. Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and β-endorphin in mice. Naunyn Schmiedebergs Arch. Pharmacol. 342(1), 67-71 (1990).

    Product Citations

    Malcolm, N.J., Palkovic, B., Sprague, D.J., et al. Mu-opioid receptor selective superagonists produce prolonged respiratory depression. iScience 26(7), 107121 (2023).