An allosteric activator of GPX4
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Activators

Research Area

Cell Biology

PKUMDL-LC-101-D04

Item No. 28966

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride
CAS Number
2143896-83-5
Molecular Formula
C14H22N4O2S2 • HCl
Formula Weight
378.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
260, 291 nm
SMILES
S=C(NC1CCCC1)NC2=CC=C(S(NCCN)(=O)=O)C=C2.Cl
InChi Code
InChI=1S/C14H22N4O2S2.ClH/c15-9-10-16-22(19,20)13-7-5-12(6-8-13)18-14(21)17-11-3-1-2-4-11;/h5-8,11,16H,1-4,9-10,15H2,(H2,17,18,21);1H
InChi Key
FELDRJSFLBINQS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $107

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    5 mg

    $396

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    Product Description

    PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4. J. Med. Chem. 62(1), 266-275 (2019).