A fluoroquinolone antibiotic
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Difloxacin (hydrochloride)

Item No. 29000

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
CAS Number
91296-86-5
Synonyms
  • A-56619
Molecular Formula
C21H19F2N3O3 • HCl
Formula Weight
435.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
281, 319, 332 nm
SMILES
OC(C1=CN(C2=CC=C(F)C=C2)C3=CC(N4CCN(C)CC4)=C(F)C=C3C1=O)=O.Cl
InChi Code
InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H
InChi Key
JFMGBGLSDVIOHL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Difloxacin is a fluoroquinolone antibiotic.1 It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 µg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bansal, M.B., and Thadepalli, H. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro. Antimicrob. Agents Chemother. 31(4), 619-621 (1987).

    2. Thadepalli, H., Gollapudi, S.V., and Chuah, S.K. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess. Antimicrob. Agents Chemother. 30(4), 574-576 (1986).