A dopamine D1 receptor agonist
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SKF 82958 (hydrobromide)

Item No. 29033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol, monohydrobromide
CAS Number
74115-01-8
Synonyms
  • (±)-6-chloro-APB
Molecular Formula
C19H20ClNO2 • HBr
Formula Weight
410.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 5 mM, with warming
SMILES
C=CCN1CCC2=C(Cl)C(O)=C(O)C=C2C(C3=CC=CC=C3)C1.Br
InChi Code
InChI=1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChi Key
WLXGFAVTAAQOFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $240

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    25 mg

    $530

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    Product Description

    SKF 82958 is a dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay).1 It is selective for dopamine D1 over D2 receptors (K0.5 = 73 nM). SKF 82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM). SKF 82958 (3 mg/kg) prevents and reverses fentanyl-induced respiratory depression, without affecting analgesia, in cats.2 It also increases locomotion and rearing in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mottola, D.M., Laiter, S., Watts, V.J., et al. Conformational analysis of D1 dopamine receptor agonists: Pharmacophore assessment and receptor mapping. J. Med. Chem. 39(1), 285-296 (1996).

    2. Lalley, P.M. D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289(1), R45-R51 (2005).

    3. Swanson, C.J., Heath, S., Stratford, T.R., et al. Differential behavioral responses to dopaminergic stimulation of nucleus accumbens subregions in the rat. Pharmacol. Biochem. Behav. 58(4), 933-945 (1997).