A class I antiarrhythmic agent
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Heart
Arrhythmia

Pirmenol

Item No. 29042

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-2-pyridinemethanol
CAS Number
68252-19-7
Synonyms
  • (±)-Pirmenol
Molecular Formula
C22H30N2O
Formula Weight
338.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 5mg/mLEthanol: 10mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
SMILES
OC(C1=NC=CC=C1)(C2=CC=CC=C2)CCCN3[C@H](C)CCC[C@@H]3C
InChi Code
InChI=1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22?
InChi Key
APUDBKTWDCXQJA-QIDMFYOTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $167

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    10 mg

    $293

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    25 mg

    $631

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    Product Description

    Pirmenol is a class I antiarrhythmic agent.1,2,3 It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.1 Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sawanobori, T., Adaniya, H., Yamashita, S., et al. Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. J. Cardiovasc. Pharmacol. 16(6), 975-983 (1990).

    2. Kaplan, H.R., Mertz, T.E., and Steffe, T.J. Preclinical pharmacology of pirmenol. Am. J. Cardiol. 59(16), 2H-9H (1987).

    3. Steffe, T.J., Mertz, T.E., Hastings, S.G., et al. CL-845 (pirmenol hydrochloride): A new orally effective long-acting antiarrhythmic agent. J. Pharmacol. Exp. Ther. 214(1), 50-57 (1980).