An internal standard for the quantification of tolnaftate
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Unlabeled Version(s)
21446Tolnaftate
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Tolnaftate-d7

Item No. 29048

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-N-(3-methylphenyl)-carbamothioic acid, O-(2-naphthalen-d7-yl) ester
CAS Number
1329835-64-4
Molecular Formula
C19H10D7NOS
Formula Weight
314.5
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
CN(C1=CC(C)=CC=C1)C(OC2=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3C([2H])=C2[2H])=S
InChi Code
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3/i3D,4D,7D,8D,10D,11D,13D
InChi Key
FUSNMLFNXJSCDI-BTSZWIDXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $75

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    1 mg

    $134

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    Cayman Chemical
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    Product Description

    Tolnaftate-d7 is intended for use as an internal standard for the quantification of tolnaftate (Item No. 21446) by GC- or LC-MS. Tolnaftate is a thiocarbamate antifungal agent.1 It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).2,3 Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.4 It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryder, N.S., Frank, I., and Dupont, M.C. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob. Agents Chemother. 29(5), 858-860 (1986).

    2. Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob. Agents Chemother. 31(9), 1365-1368 (1987).

    3. Waitz, J.A., Moss, E.L., and Weinstein, M.J. Chemotherapeutic evaluation of clotrimazole [Bay b 5097, 1 (o-chloro-α-α-diphenylbenzyl) imidazole]. Appl. Microbiol. 22(5), 891-898 (1971).

    4. Khan, S.N., Maggon, K.K., and Venkitasubramanian, T.A. Inhibition of aflatoxin biosynthesis by tolnaftate. Appl. Environ. Microbiol. 36(2), 270-273 (1978).