An internal standard for the quantification of palonosetron
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Unlabeled Version(s)
16752Palonosetron (hydrochloride)
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Palonosetron-d3 (hydrochloride)

Item No. 29049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-((S)-quinuclidin-3-yl-3-d)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one-3,3-d2, monohydrochloride
Synonyms
  • RS 25259-197-d3
Molecular Formula
C19H21D3N2O • HCl
Formula Weight
335.9
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(N([C@@]1([2H])C(CC2)CCN2C1)C3([2H])[2H])C4=CC=CC5=C4[C@]3([H])CCC5.Cl
InChi Code
InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1/i11D2,17D;
InChi Key
OLDRWYVIKMSFFB-RAVRUBKISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $217

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    Product Description

    Palonosetron-d3 is intended for use as an internal standard for the quantification of palonosetron (Item No. 16752) by GC- or LC-MS. Palonosetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.04 nM).1 It is selective for 5-HT3 over 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = ≥15.85 μM for all), as well as a panel of additional neurotransmitter receptors. Palonosetron inhibits 5-HT-induced contraction in isolated guinea pig ileum. It inhibits cisplatin-induced emesis in ferrets (ID50 = 1.1 μg/kg, i.v.) as well as emesis induced by cisplatin (Item No. 13119), dacarbazine (Item No. 21877), actinomycin D (Item No. 11421), and mechlorethamine in dogs (ID50s = 1.9, 4.1, 4.9, and 4.4 μg/kg, respectively).2 Formulations containing palonosetron have been used in the treatment of postoperative or chemotherapy-induced nausea and vomiting.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, E.H., Clark, R., Leung, E., et al. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br. J. Pharmacol. 114(4), 851-859 (1995).

    2. Eglen, R.M., Lee, C.H., Smith, W.L., et al. Pharmacological characterization of RS 25259-197, a novel and selective 5-HT3 receptor antagonist, in vivo. Br. J. Pharmacol. 114(4), 860-866 (1995).