A mixture of locostatin isomers
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Product Type

Biochemicals

Research Area

(E/Z)-Locostatin

Item No. 29092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-2-oxazolidinone
CAS Number
133812-16-5
Molecular Formula
C14H15NO3
Formula Weight
245.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLEthanol: 10mg/mLEthanol:PBS (pH 7.2) (1:6): 0.14mg/mL
λmax
213, 217, 226 nm
SMILES
O=C1N(C(/C=C/C)=O)[C@@H](CC2=CC=CC=C2)CO1
InChi Code
InChI=1S/C14H15NO3/c1-2-6-13(16)15-12(10-18-14(15)17)9-11-7-4-3-5-8-11/h2-8,12H,9-10H2,1H3/b6-2+/t12-/m0/s1
InChi Key
UTZAFVPPWUIPBH-QSLRECBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $95

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    50 mg

    $363

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    100 mg

    $655

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    Product Description

    (E/Z)-Locostatin is a mixture of (E)-locostatin and (Z)-locostatin. (E)-Locostatin inhibits the protein-protein interaction between Raf and phosphatidylethanolamine-binding protein 1 (PEBP1) and the migration and wound closure activities of MDCK kidney cells (IC50 = 14 µM).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mc Henry, K.T., Ankala, S.V., Ghosh, A.K., et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem 3(11), 1105-1111 (2002).

    2. Zhu, S., Mc Henry, K.T., Lane, W.S., et al. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem. Biol. 12(9), 981-991 (2005).