A fluoroquinolone antibiotic
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Pefloxacin (mesylate hydrate)

Item No. 29103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate, dihydrate
CAS Number
149676-40-4
Molecular Formula
C17H20FN3O3 • CH3SO3H [2H2O]
Formula Weight
465.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
λmax
280, 318, 332 nm
SMILES
O=C1C2=CC(F)=C(N3CCN(C)CC3)C=C2N(CC)C=C1C(O)=O.CS(=O)(O)=O.O.O
InChi Code
InChI=1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChi Key
LEULAXMUNMRLPW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

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    Cayman Chemical
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    Product Description

    Pefloxacin is a broad-spectrum and synthetic fluoroquinolone antibiotic and a methylated derivative of norfloxacin (Item No. 25975).1,2 It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, S. aureus, and G. vaginalis (MIC90s = 0.12, 0.5, 0.5, and 32 mg/L, respectively).1,2 Pefloxacin selectively inhibits E. coli topoisomerase I and DNA gyrase over calf thymus topoisomerase I (IC50s = 45, 4.5, and >140 μg/ml, respectively) in cell-free assays.3 In vivo, pefloxacin is active against systemic E. coli, K. pneumoniae, and P. aeruginosa infections in mice with 50% of efficacy maximum (P50) values of 6.5, 29.2, and 219 mg/kg, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clarke, A.M., Zemcov, S.J., and Campbell, M.E. In-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new β-lactams. J. Antimicrob. Chemother. 15(1), 39-44 (1985).

    2. Jones, B.M., Geary, I., Lee, M.E., et al. Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections. J. Antimicrob. Chemother. 17(6), 736-746 (1986).

    3. Tabary, X., Moreau, N., Dureuil, C., et al. Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I. Antimicrob. Agents Chemother. 31(12), 1925-1928 (1987).

    4. Fantin, B., Leggett, J., Ebert, S., et al. Correlation between in vitro and in vivo activity of antimicrobial agents against gram-negative bacilli in a murine infection model. Antimicrob. Agents Chemother. 35(7), 1413-1422 (1991).