An L-type calcium channel blocker
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Lercanidipine (hydrochloride)

Item No. 29104

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, monohydrochloride
CAS Number
132866-11-6
Molecular Formula
C36H41N3O6 • HCl
Formula Weight
648.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMF:PBS (pH 7.2) (1:2): 0.3mg/mLDMSO: 15mg/mLEthanol: 2mg/mL
λmax
239, 363 nm
SMILES
CC(NC(C)=C1C(OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)=O)=C(C(OC)=O)C1C4=CC([N+]([O-])=O)=CC=C4.Cl
InChi Code
InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
InChi Key
WMFYOYKPJLRMJI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $42

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    100 mg

    $74

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    250 mg

    $132

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    500 mg

    $242

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    Product Description

    Lercanidipine is a dihydropyridine L-type calcium channel blocker.1 It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure (DBP) in normotensive and spontaneously hypertensive rats with ED25 values of 16.3 and 15.5 µg/kg, respectively. Formulations containing lercanidipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Testa, R., Leonardi, A., Tajana, A., et al. Lercanidipine (Rec 15/2375): A novel 1,4-dihydropyridine calcium antagonist for hypertension. Cardiovasc. Drug Rev. 15(3), 187-219 (1997).