A stilbene with diverse biological activities
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4'-O-Methylresveratrol

Item No. 29106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1E )-2-(4-methoxyphenyl)ethenyl]-1,3-benzenediol
CAS Number
33626-08-3
Synonyms
  • Deoxyrhapontigenin
  • trans-3,5-Dihydroxy-4′-methoxystilbene
  • 4-Methoxyresveratrol
Molecular Formula
C15H14O3
Formula Weight
242.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
216, 305, 319 nm
SMILES
OC1=CC(O)=CC(/C=C/C2=CC=C(OC)C=C2)=C1
InChi Code
InChI=1S/C15H14O3/c1-18-15-6-4-11(5-7-15)2-3-12-8-13(16)10-14(17)9-12/h2-10,16-17H,1H3/b3-2+
InChi Key
IHVRWFJGOIWMGC-NSCUHMNNSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $185

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    25 mg

    $435

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    50 mg

    $770

    Add
    Cayman Chemical
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    Product Description

    4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.1,2,3,4 It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 µg/ml, respectively).1 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).2 It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.3 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryu, S.Y., Choi, S.U., Lee, C.O., et al. Antitumor activity of some phenolic components in plants. Arch. Pharm. Res. 17, 42-44 (1994).

    2. Ko, S.K., Lee, S.M., and Whang, W.K. Anti-platelet aggregation activity of stilbene derivatives from Rheum Undulatum. Arch. Pharm. Res. 22(4), 401-403 (1999).

    3. Kerem, Z., Regev-Shoshani, G., Flaishan, M.A., et al. Resveratrol and two monomethylated stilbenes from Israeli Rumex bucephalophorus and their antioxidant potential. J. Nat. Prod. 66(9), 1270-1272 (2003).

    4. Tran, P.T., Park, D.-H., Kim, O., et al. Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss. Int. J. Mol. Med. 42(1), 569-578 (2018).