A prodrug form of monomethyl fumarate
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Active Metabolite(s)
27813Monomethyl fumarate
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Diroximel Fumarate

Item No. 29111

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-butenedioic acid, 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester
CAS Number
1577222-14-0
Synonyms
  • BIIB098
Molecular Formula
C11H13NO6
Formula Weight
255.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
SMILES
COC(/C=C/C(OCCN1C(CCC1=O)=O)=O)=O
InChi Code
InChI=1S/C11H13NO6/c1-17-10(15)4-5-11(16)18-7-6-12-8(13)2-3-9(12)14/h4-5H,2-3,6-7H2,1H3/b5-4+
InChi Key
YIMYDTCOUQIDMT-SNAWJCMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $370

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    50 mg

    $609

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    Cayman Chemical
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    Product Description

    Diroximel fumarate is a prodrug form of monomethyl fumarate (Item No. 27813).1 It undergoes esterase cleavage in the gut to release monomethyl fumarate. Formulations containing diroximel fumarate have been used in the treatment of relapsing-remitting multiple sclerosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Naismith, R.T., Wolinsky, J.S., Wundes, A., et al. Diroximel fumarate (DRF) in patients with relapsing-remitting multiple sclerosis: Interim safety and efficacy results from the phase 3 EVOLVE-MS-1 study. Mult. Scler. (2019).