An antimicrobial and radiosensitizer
Related Products
Isomer(s)
30067RGW 611
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nimorazole

Item No. 29153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(5-nitro-1H-imidazol-1-yl)ethyl]-morpholine
CAS Number
6506-37-2
Synonyms
  • Acterol
  • Naxofem
  • Naxogin
  • Nitrimidazine
  • NSC 107524
Molecular Formula
C9H14N4O3
Formula Weight
226.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMF:PBS (pH 7.2) (1:3): 0.25mg/mLDMSO: 10mg/mLEthanol: 2mg/mL
SMILES
O=[N+](C1=CN=CN1CCN2CCOCC2)[O-]
InChi Code
InChI=1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2
InChi Key
MDJFHRLTPRPZLY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $38

    Add

    25 mg

    $66

    Add

    50 mg

    $102

    Add

    100 mg

    $183

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.1,2,3 It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).1,2 Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).4 Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brotherton, J. Biological assay of potential trichomonacides in vitro using a counter apparatus. Arzneimittelforschung 28(10), 1665-1672 (1978).

    2. Boreham, P.F., Phillips, R.E., and Shepherd, R.W. A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis. J. Antimicrob. Chemother. 16(5), 589-595 (1985).

    3. Sugie, C., Shibamoto, Y., Ito, M., et al. Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo. J. Radiat. Res. 46(4), 453-459 (2005).

    4. Meingassner, J.G. Comparative studies on the trichomonacidal activity of 5-nitroimidazole-derivatives in mice infected s.c. or intravaginally with T. vaginalis. Experientia 33(9), 1160-1161 (1977).