A terpene trilactone with diverse biological activities
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Isomer(s)
14636Ginkgolide B
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Ginkgolide J

Item No. 29163

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)hexahydro-2,4,7b-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
CAS Number
107438-79-9
Synonyms
  • BN 52024
Molecular Formula
C20H24O10
Formula Weight
424.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 10 mg/ml
SMILES
O=C(O1)[C@@H](C)[C@@]2(O)[C@]1([H])C[C@]34[C@@]25O[C@@]6([H])C3([C@@H](O)C(O6)=O)[C@H](C(C)(C)C)[C@@H](O)[C@@]4([H])OC5=O
InChi Code
InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-11-8(21)9(16(2,3)4)18(17)10(22)13(24)29-15(18)30-20(17,14(25)28-11)19(6,7)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11-,15+,17-,18?,19-,20-/m1/s1
InChi Key
LMEHVEUFNRJAAV-FRUIKCAPSA-N
Origin
Plant/Ginkgo biloba
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. 1,2,3 It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).2 Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Braquet, P., Esanu, A., Buisine, E., et al. Recent progress in ginkgolide research. Med. Res. Rev. 11(3), 295-355 (1991).

    2. Koch, E. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: Considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12(1-2), 10-16 (2005).

    3. Vitolo, O., Gong, B., Cao, Z., et al. Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol. Aging 30(2), 257-265 (2009).