A positive allosteric modulator of group III mGluRs
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ML-396

Item No. 29167

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
CAS Number
1630936-95-6
Synonyms
  • VU0422288
Molecular Formula
C17H11Cl2N3O2
Formula Weight
360.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleDMSO: slightly soluble
SMILES
O=C(NC1=CC(Cl)=C(OC2=CC=C(Cl)C=N2)C=C1)C3=CC=CC=N3
InChi Code
InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
InChi Key
MZRLPXFGQKQHST-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    25 mg

    $462

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    Product Description

    ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.1 ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jalan-Sakrikar, N., Field, J.R., Klar, R., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem. Neurosci. 5(12), 1221-1237 (2014).

    2. Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci. Transl. Med. 9(403), (2017).