A TRPV4 antagonist
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RN-9893 (hydrochloride)

Item No. 29172

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)-benzamide, monohydrochloride
CAS Number
2109450-40-8
Molecular Formula
C21H23F3N4O5S • HCl
Formula Weight
537.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
FC(F)(F)C1=CC=C(C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)=O)C([N+]([O-])=O)=C1.Cl
InChi Code
InChI=1S/C21H23F3N4O5S.ClH/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31;/h3-8,13-14H,9-12H2,1-2H3,(H,25,29);1H
InChi Key
ULUOUAGDTULBRZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $120

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    Product Description

    RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate (4α-PDD; Item No. 20446) or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wei, Z.L., Nguyen, M.T., O'Mahony, D.J., et al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg. Med. Chem. Lett. 25(18), 4011-4015 (2015).