A synthetic bile acid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Dehydrocholic Acid

Item No. 29176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3,7,12-trioxo-cholan-24-oic acid
CAS Number
81-23-2
Synonyms
  • NSC 8796
  • 3,7,12-Triketocholanic Acid
  • Triketocholanoic Acid
Molecular Formula
C24H34O5
Formula Weight
402.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]([C@]21C)([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
InChi Code
InChI=1S/C24H34O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-14,16-18,22H,4-12H2,1-3H3,(H,28,29)/t13-,14+,16-,17+,18+,22+,23+,24-/m1/s1
InChi Key
OHXPGWPVLFPUSM-KLRNGDHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $36

    Add

    5 g

    $103

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Dehydrocholic acid is a synthetic bile acid and a derivative of cholic acid (Item No. 20250).1 It increases bile flow by 2.7-fold and decreases biliary levels of phospholipids, cholesterol, and bilirubin in conscious dogs when administered at a dose of 50 mg/kg.2 Dehydrocholic acid (1 µmol/min/0.1 kg) increases bile flow by 253% and decreases the secretion rate of phospholipids and cholesterol by 64 and 94%, respectively, in rats when infused intravenously at a dose of 2 µmol/min/0.1 kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Soloway, R.D., Hofmann, A.F., Thomas, P.J., et al. Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man. J. Clin. Invest. 52(3), 715-724 (1973).

    2. Yanaura, S., and Ishikawa, S. Choleretic properties of ursodeoxycholic acid and chenodeoxycholic acid in dogs. Jpn. J. Pharmacol. 28(3), 383-389 (1978).

    3. Yousef, I.M., Mignault, D., Weber, A.M., et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion 45(1), 40-51 (1990).