A benzamide
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CPI-1189

Item No. 29187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-N-(1,1-dimethylethyl)-benzamide
CAS Number
183619-38-7
Molecular Formula
C13H18N2O2
Formula Weight
234.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMSO: 20mg/mLEthanol: 20mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
λmax
265 nm
SMILES
CC(NC1=CC=C(C(NC(C)(C)C)=O)C=C1)=O
InChi Code
InChI=1S/C13H18N2O2/c1-9(16)14-11-7-5-10(6-8-11)12(17)15-13(2,3)4/h5-8H,1-4H3,(H,14,16)(H,15,17)
InChi Key
DJKNRCWSXSZACF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $36

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    50 mg

    $63

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    100 mg

    $108

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    250 mg

    $219

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    Product Description

    CPI-1189 is a benzamide with neuroprotective and anti-inflammatory activities.1,2,3,4,5 It inhibits phosphorylation of p38 MAPK in IL-1β-stimulated primary rat astrocytes by 70 to 80% when used at concentrations ranging from 10 to 300 nM.1 CPI-1189 (20 mg/kg per day) reduces TNF-α-induced apoptosis in the corpus callosum and septum, but not in the neocortex or basal ganglia, as well as reduces TNF-α-induced decreases in GFAP levels in isolated rat brain slices.2 It decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, induced by TNF-α in a rat model of AIDS dementia when administered at a dose of 20 mg/kg per day.3 CPI-1189 (30 mg/kg per day) reduces crypt loss and decreases the number of ulcers and inflammatory cells in colonic lesions in mouse models of colitis induced by TNBS or dextran sulfate sodium (DSS; Item No. 23250).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hensley, K., Robinson, K.A., Pye, Q.N., et al. CPI-1189 inhibits interleukin 1β-induced p38-mitogen-activated protein kinase phosphorylation: An explanation for its neuroprotective properties? Neurosci. Lett. 281(2-3), 179-182 (2000).

    2. Bjugstad, K.B., Flitter, W.D., Garland, W.A., et al. CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-α infusion model for AIDS dementia complex. J. Neurovirol. 6(6), 478-491 (2000).

    3. Bjugstad, K.B., Flitter, W.D., Garland, W.A., et al. Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia. Brain Res. 795(1-2), 349-357 (1998).

    4. Greenwood-Van Meerveld, B., and Tyler, K. CPI-1189 protects against TNBS-induced colitis in a rodent model. Am. J. Pharmacol. Toxicol. 2(2), 30-38 (2007).

    5. Greenwood-Van Meerveld, B., and Tyler, K.R. CPI-1189 protects against dextran sulfate sodium-induced colitis in mice. Am. J. Pharmacol. Toxicol. 1(3), 54-59 (2006).