A positive allosteric modulator of AMPA receptors
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PEPA

Item No. 29190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-acetamide
CAS Number
141286-78-4
Molecular Formula
C16H16F2N2O4S2
Formula Weight
402.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 3 mg/ml
λmax
258 nm
SMILES
FC1=C(OCC(N)=O)C(F)=CC(SCCNS(C2=CC=CC=C2)(=O)=O)=C1
InChi Code
InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
InChi Key
GTACSIONMHMRPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $97

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    10 mg

    $134

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    Product Description

    PEPA is a positive allosteric modulator (PAM) of AMPA receptors.1 It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).2 It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sekiguchi, M., Fleck, M.W., Mayer, M.L., et al. A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J. Neurosci. 17(15), 5760-5771 (1997).

    2. Sekiguchi, M., Yamada, K., Jin, J., et al. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 12(13), 2947-29950 (2001).

    3. Zushida, K., Sakurai, M., Wada, K., et al. Facilitation of extinction learning for contextual fear memory by PEPA: A potentiator of AMPA receptors. J. Neurosci. 27(1), 158-166 (2007).