An inducer of HSP70 expression
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TRC051384

Item No. 29199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-morpholinyl)ethyl]-N′-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-urea
CAS Number
867164-40-7
Molecular Formula
C25H31N5O4
Formula Weight
465.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml
SMILES
O=C(NC1=CC=C(C(/C=C/C2=CC=CC(N3CCOCC3)=N2)=O)C=C1)NCCN4CCOCC4
InChi Code
InChI=1S/C25H31N5O4/c31-23(9-8-21-2-1-3-24(27-21)30-14-18-34-19-15-30)20-4-6-22(7-5-20)28-25(32)26-10-11-29-12-16-33-17-13-29/h1-9H,10-19H2,(H2,26,28,32)/b9-8+
InChi Key
SQTSPANZQDCPLB-CMDGGOBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $178

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    10 mg

    $333

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    Product Description

    TRC051384 is an inducer of heat shock protein 70 (HSP70) expression.1 It increases HSP70 mRNA in HeLa cells and primary rat neurons when used at concentrations of 6.3 and 12.5 µM and activates the transcription factor heat shock factor 1 (Hsf1) in a reporter assay using HeLa cells at 25 µM. TRC051384 (1 µM) reduces apoptosis, decreases the levels of malondialdehyde (MDA), and prevents a decrease in the mitochondrial membrane potential induced by tert-butyl hydroperoxide in isolated human nucleus pulposus stem cells (NPSCs).2 Intraperitoneal administration of TRC051384 reduces penumbral incorporation into initial lesions, increases the percentage of animals surviving, and lowers neurological deficit scores in a rat model of cerebral ischemia.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mohanan, A., Deshpande, S., Jamadarkhana, P.G., et al. Delayed intervention in experimental stroke with TRC051384—A small molecule HSP70 inducer. Neuropharmacology 60(6), 991-999 (2011).

    2. Zhang, S., Liu, W., Wang, P., et al. Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway. Mol. Cell. Biochem. 476(5), 1979-1994 (2021).