An inhibitor of Wnt/β-catenin signaling

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC Questionnaire Download WB Questionnaire

First Name

Last Name

Institution

Country

State

Telephone (optional)

Product Name (optional)

Catalog Number (optional)

Batch Number (optional)

Message(0 / 2000)

Add an attachment (max size ~5mb) (optional)

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Research Area

KYA1797K

Name: KYA1797K
Brand: -

Item No. 29221

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

(5Z)-5-[[5-(4-nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid, monopotassium salt

CAS Number

1956356-56-1

Molecular Formula

C₁₇H₁₁N₂O₆S₂ • K

Formula Weight

442.5

Purity

≥95%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: Partially solubleDMSO: 0.5 mg/mlEthanol: Partially solublePBS (pH 7.2): 0.3 mg/ml

λ_max

240, 327, 436 nm

SMILES

O=C(N(CCC([O-])=O)C(S/1)=S)C1=C\C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2.[K+]

InChi Code

InChI=1S/C17H12N2O6S2.K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24;/h1-6,9H,7-8H2,(H,20,21);/q;+1/p-1/b14-9-;

InChi Key

PHUNRLYHXGMOLG-WQRRWHLMSA-M

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

5 mg

$90

Add

10 mg

$158

Add

25 mg

$349

Add

50 mg

$609

Add

Visit Our Cancer Resource Center

Find Tools & Resources to Study the Hallmarks of Cancer

Cancer cell signaling & regulation
Cancer metabolism
Tumor microenvironment

EXPLORE NOW

Product Description

KYA1797K is an inhibitor of Wnt/β-catenin signaling.¹ It inhibits expression of a reporter induced by Wnt3a-conditioned medium in HEK293 cells (IC₅₀ = 0.75 μM). KYA1797K binds to the regulators of G-protein signaling (RGS) domain of axin and increases activation of GSK3β, as well as phosphorylation of β-catenin and Ras, in HEK293 cells when used at a concentration of 25 μM. It decreases β-catenin and Ras protein levels and inhibits colony formation in SW480 cells in a concentration-dependent manner. KYA1797K inhibits the growth of SW480, LoVo, DLD1, and HCT15 cells (GI₅₀s = 5, 4.8, 4.5, and 4.2 μM, respectively). It reduces tumor growth in a D-MT colorectal cancer mouse xenograft model when administered at a dose of 20 mg/kg.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Cha, P.-H., Cho, Y.-H., Lee, S.-K., et al. Small-molecule binding of the axin RGS domain promotes β-catenin and ras degradation. Nat. Chem. Biol. 12(8), 593-600 (2016).

Cart Subtotal:$0